Tumor Microenvironment and Pancreatic Cancer
نویسندگان
چکیده
منابع مشابه
Seed-in-Soil: Pancreatic Cancer Influenced by Tumor Microenvironment
Pancreatic ductal adenocarcinoma is a fatal malignancy with a five-year survival rate lower than 7%, and most patients dying within six months of diagnosis. The factors that contribute to the aggressiveness of the disease include, but are not limited to: late diagnosis, prompt metastasis to adjacent vital organs, poor response, and resistance to anticancer treatments. This malignancy is uniquel...
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Reg3β is up-regulated in serum and pancreatic juice from patients with pancreatic ductal adenocarcinoma. However, whether such expression is relevant to the development of tumors has not yet been carefully examined. We have recently demonstrated that silencing Reg3β in a pancreatic cancer model impaired tumor growth by skewing macrophage polarization. Pancreatic ductal adenocarcinoma (PDAC) con...
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Introduction. In spite of intensive research during many years, pancreatic adenocarcinoma remains one of the deadliest cancers. The surgical intervention remains main possibility of treatment because chemotherapy and radiotherapy has a minimal impact on long-term survival. We are still looking for the weak points of this devastating disease. Materials and Methods. Pancreatic tumor tissue sample...
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Since pancreatic carcinoma is largely refractory to conventional therapies, development of novel agents is required for the effective treatment of pancreatic cancer. The objective of this paper was to examine the molecular mechanisms by which embelin inhibited human pancreatic cancer growth in mice by modulating tumor immune microenvironment. Embelin inhibited PANC-1 tumor growth, angiogenesis,...
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Background Recent studies revealed that tumor-associated macrophages (TAMs) play a decisive role in the regulation of tumor progression by manipulating tumor oncogenesis, angiogenesis and immune functions within tumor microenvironments. Signal transducer and activator of transcription 3 (STAT3), which is a point of convergence for numerous oncogenic signalling pathways, is constitutively activ...
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ژورنال
عنوان ژورنال: Molecular Biology: Open Access
سال: 2012
ISSN: 2168-9547
DOI: 10.4172/2168-9547.1000e104